David Andrew Sinclair, a biologist, professor of genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, is best known for his work on understanding why we age and how to slow the effects of aging. . To date, Dr. Sinclair has chosen not to promote or endorse any nutritional supplement for the purpose of slowing aging and its symptoms, but also for a better quality of life in general. However, from time to time in interviews and books he writes, he refers to various preparations that he himself receives. Specifically, so far the ones he has mentioned are a series of 12 substances, most of them natural, however it is unknown if the list is complete or if there are additional substances that he has not disclosed to the public. The list that has emerged from the statements of Dr. Sinclair, regarding substances that “promise” longevity and slowing down the health problems caused by old age is formulated as follows:
- Nicotinamide mononucleotide (NMN)
It is a substance present in certain green vegetables, and it has the property of reducing the signs of aging, as reported by scientists from the Washington University School of Medicine in St. Louis. We find it in abundance in broccoli, cabbage, avocado, cucumber, soybeans, tomatoes, etc.
- Resveratrol
It is a plant compound that acts as an antioxidant. It is mainly found in red wine, grapes, some berries and peanuts and studies have shown that it can reduce the risk of heart disease, cancer and neurodegeneration. Studies show positive results, in relation to various diseases such as heart disease and arthritis.
- Metformin
This is a prescription drug used to treat high blood sugar levels. In the studies done, it was found that diabetics taking metformin lived longer than healthy non-diabetics apparently not taking metformin. However, taking metformin can have side effects and doctors’ instructions should be followed closely.
- Vitamin D3
The human body receives vitamin D from the sun and certain foods. Its deficiency has been associated with an increased risk of heart disease, type 2 diabetes, autoimmune diseases and Alzheimer’s disease. We can also get vitamin D from certain foods, such as fish, cod liver oil, beef liver, egg, milk, etc.
- Vitamin K2
Vitamin K is important for bone health as well as blood vessels and mitochondria, while it improves skin health. Some scientists argue that people at risk of heart disease should regularly use vitamin K2 supplements, while others point out that more studies are needed before any solid recommendations can be made.
- Statin
It is a prescription drug to lower cholesterol, but statins are also associated with a lower risk of heart disease and stroke. But scientists are not entirely sure whether someone should take statin drugs before they have a significant problem with their cholesterol levels, damage to their arteries, or a heart attack.
- Low-dose aspirin
Taking aspirin daily – even in small doses – can reduce the risk of heart attack and stroke, but daily aspirin therapy isn’t for everyone. Daily low-dose aspirin therapy may be recommended for the primary prevention of heart attack or stroke only for those who meet certain age and medical conditions.
- Alpha-lipoic acid
It is an organic compound that has been discussed very often in recent years. It acts as a powerful antioxidant in the body. Our bodies produce alpha-lipoic acid naturally, but we can also find it in a variety of foods. Studies show that it may play a role in weight loss and mainly fights diabetes, but scientists have not yet come to certain conclusions.
- Coenzyme Q10
Coenzyme Q10 (CoQ10) is an antioxidant that the human body produces naturally. Our cells use CoQ10 for growth and maintenance, levels of which decline as we age. We find it mainly in meat, fish and nuts, but the amount found in these foods is not enough to significantly increase Q10 levels in our body.
- Spermidine
Spermidine has anti-inflammatory properties, antioxidant activity and enhances mitochondrial metabolism. Studies have shown that it can improve various biomarkers of health and longevity and can extend lifespan in different organisms, including mice. As a supplement, spermidine is extracted from wheat germ. It can also be found in foods such as cheese, soy, legumes and mushrooms, whole grains, red wine, etc.
- Quercetin & fisetin
Fisetin is a natural substance found in fruits and vegetables such as strawberries, apples, grapes, onions and cucumbers. Quercetin is a natural pigment found in many fruits, vegetables and grains. Quercetin and fisetin are very similar substances and are thought to be able to “cleanse” aging cells.
- TMG (trimethylglycine or betaine)
It is a compound that the body produces naturally but is also found in supplements and some foods. It has been studied for many potential health benefits, including its ability to boost heart health, enhance athletic performance, promote healthy insulin levels, and protect against depression. However, it can also cause side effects, especially if used in high doses.
