{"id":7494,"date":"2022-02-03T19:19:39","date_gmt":"2022-02-03T17:19:39","guid":{"rendered":"http:\/\/www.liberalglobe.com\/?p=7494"},"modified":"2022-02-03T19:19:43","modified_gmt":"2022-02-03T17:19:43","slug":"hiv-a-cure-for-cancer-may-pave-the-way-for-a-complete-cure-of-the-virus","status":"publish","type":"post","link":"https:\/\/www.liberalglobe.com\/?p=7494","title":{"rendered":"HIV: A Cure for Cancer May Pave the Way for a Complete Cure of the Virus"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Immunotherapy used to treat various cancers seems to prevent HIV from hiding permanently inside immune system cells, a finding that may eventually pave the way for a complete cure for the infection.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Today&#8217;s antiviral drugs inhibit proliferation and allow carriers to live normal lives without AIDS symptoms. But they can not completely eradicate the virus, which can hide in the CD4 + cells of the immune system and remain dormant until it has a chance to be activated.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">MSD (Merck in the USA) Pemprolizumab is a monoclonal antibody that blocks the PD-1 protein, which is used by cancer cells to prevent the immune system from attacking.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The same protein is found in CD4 + cells that are infected with HIV. According to a new study published in Science Translational Medicine, entitled &#8220;Pembrolizumab induces HIV latency reversal in people living with HIV and cancer on antiretroviral therapy&#8221; (<a href=\"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abl3836\">https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.abl3836<\/a>) Pemprolizumab reverses the latent state of the virus and forces it to reproduce in CD4 + cells. Potentially, virus activation could allow the immune system to recognize and destroy infected cells.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The study was performed on 32 cancer patients who also had HIV and were receiving antiviral therapy. Following treatment, the virus RNA was detected in the CD4 + cells and plasma of the patients, indicating that the latent virus had been activated.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Research will continue in the hope that the monoclonal antibody will allow the immune system to kill HIV-infected cells as it kills cancer.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Meanwhile, Excision Biotherapeutics is preparing to begin clinical trials of a treatment based on the revolutionary CRISPR technique that has given encouraging results in eradicating HIV from mice.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Immunotherapy used to treat various cancers seems to prevent HIV from hiding permanently inside immune system cells, a finding that may eventually pave the&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,2993,2958],"tags":[3281,3279,3280],"class_list":["post-7494","post","type-post","status-publish","format-standard","hentry","category-health","category-life","category-medical","tag-hiv","tag-immunotherapy","tag-monoclonal-antibodies"],"_links":{"self":[{"href":"https:\/\/www.liberalglobe.com\/index.php?rest_route=\/wp\/v2\/posts\/7494","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.liberalglobe.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.liberalglobe.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.liberalglobe.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.liberalglobe.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7494"}],"version-history":[{"count":1,"href":"https:\/\/www.liberalglobe.com\/index.php?rest_route=\/wp\/v2\/posts\/7494\/revisions"}],"predecessor-version":[{"id":7496,"href":"https:\/\/www.liberalglobe.com\/index.php?rest_route=\/wp\/v2\/posts\/7494\/revisions\/7496"}],"wp:attachment":[{"href":"https:\/\/www.liberalglobe.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7494"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.liberalglobe.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7494"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.liberalglobe.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}